Mixed T cell receptor dimers harbor potentially harmful neoreactivity

Mixed T cell receptor dimers harbor potentially harmful neoreactivity.

Adoptive transfer of T cell receptor (TCR)-transduced T cells may be an attractive strategy to target both hematological malignancies and solid tumors. By introducing a TCR, large numbers of T cells with defined antigen (Ag) specificity can be obtained. However, by introduction of a TCR, mixed TCR dimers can be formed. Besides the decrease in TCR expression of the introduced and endogenous TCR,...

T Cell Receptor Transfer to T Cells Generates Functional Effector Cells without Mixed TCR Dimers In Vivo

Do protective lead garments harbor harmful bacteria?

This study attempted to identify and characterize bacteria present on shared-use protective lead shielding garments worn in the operating room. Those worn at the authors' institution were collected and swabbed in designated 5×5-cm areas. Swabs were sent to the clinical laboratory for bacterial isolation and identification. All isolates were identified using standard microbiological methods. Iso...

Tumors Harbor Multiple Potentially Actionable Kinase Fusions

Infl ammatory myofi broblastic tumor (IMT) is a neoplasm that typically occurs in children. The genetic landscape of this tumor is incompletely understood and therapeutic options are limited. Although 50% of IMTs harbor anaplastic lymphoma kinase ( ALK) rearrangements, no therapeutic targets have been identifi ed in ALK-negative tumors. We report for the fi rst time that IMTs harbor other actio...

Iridology: not useful and potentially harmful.

More than 1,000 licensed naturopathic physicians practice in the United States, and iridology is being described as "the most valuable diagnostic tool of the naturopath." Some therapists are using iridology as a basis for recommending dietary supplements and/or herbs. Several US iridologist organizations exist: the National Iridology Research Association is an iridologists' service organization...